Figure_6.tif (268.73 kB)
Estimation results for different values of mutation rates m.
figure
posted on 2010-04-15, 01:20 authored by Bambang S. Adiwijaya, Eva Herrmann, Brian Hare, Tara Kieffer, Chao Lin, Ann D. Kwong, Varun Garg, John C. R. Randle, Christoph Sarrazin, Stefan Zeuzem, Paul R. CaronPanel a, maximum likelihood objective values for mutation rates m of 1.2×10−5/cycle, 1.2×10−4/cycle, 1.2×10−3/cycle, and 1.2×10−2/cycle. The objective functions are the lowest with m = 1.2×10−4/cycle, suggesting models fit data best with this m value. Panel b, estimated fitness of selected variants at different m values. Similar ranking of fitness estimates were obtained with these different values of mutation rates. Similar fitness estimates suggests robustness to the assumed mutation rate m. Fitness estimates for m = 1.2×10−2/cycle were not reported because of poor model fits.