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Enhanced cytokine recall responses of cblb-silenced CD8+ T cell tumor infiltrates.

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posted on 2013-02-20, 00:00 authored by Reinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Alexander Tzankov, Manfred Schuster, Josef M. Penninger, Hans Loibner, Günther Lametschwandtner, Dominik Wolf, Gottfried Baier

Tumor infiltrating CD8+ T cells either nucleofected with control siRNA or cblb siRNA were ex vivo stimulated with unloaded or SIINFEKL loaded DCs and (A) IL-2 as well as (B) IFNγ secretion was measured by BioPlex technology. Means ± SEM of four independent experiments are shown. (A) p = 0.03 (SIINFEKL loaded DC+CD8+cblb siRNA versus SIINFEKL loaded DC+CD8+ control siRNA), (B) p = 0.05 (SIINFEKL loaded DC+CD8+cblb siRNA versus SIINFEKL loaded DC+CD8+ control siRNA).

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