Effects of TLCA on HDAC4 expression in cultured primary HSCs.

TLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar). HSCs of miR-29a transgenic mice (gray bar) exhibited significantly reduced upregulation and nuclear translation of HDAC4 in response to TLCA stimulation. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.