Fig_4.tif (803.61 kB)
Effects of TLCA on HDAC4 expression in cultured primary HSCs.
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posted on 2015-08-25, 03:07 authored by Ying-Hsien Huang, Mao-Meng Tiao, Li-Tung Huang, Jiin-Haur Chuang, Kuang-Che Kuo, Ya-Ling Yang, Feng-Sheng WangTLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar). HSCs of miR-29a transgenic mice (gray bar) exhibited significantly reduced upregulation and nuclear translation of HDAC4 in response to TLCA stimulation. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.
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HDAC 4Histone Deacetylases 4 BackgroundRecent studiesHDAC 4 functionprofibrogenic gene expressionhistone deacetylases 4migration assays.ResultsAfter BDLHSC migrationcholestatic liver fibrosisglial fibrillary acidic protein expressionprofibrogenic phenotypeantisense inhibitormirHSC activationHepatic Stellate CellsHSC proliferation.ConclusionsOur resultsActivated Hepatic Stellate Cells Modulates
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