Effects of IGF and chemerin on Ca2+ signalling in MSCs.

A. Images of Fluo-4 loaded MSCs taken in the absence (left) and the presence (right) of chemerin (100nM), respectively. B. IGF-II (100 ng.ml-1, top) and chemerin (100nM, Ch) induce Ca2+ oscillations in Fluo-4 loaded cells. C. Relaxation of Ca2+ transients induced by chemerin or IGF-II after removal of external Ca2+ (Ca2+ free solution with 2mM EGTA).