Effect of plant stanols on macrophages <i>in vitro</i>.

<p>Changes in Tnf-α concentrations in supernatant and LXR target gene expression of bone marrow derived macrophages after incubation with sitostanol (0.6 and 1.2 µm) or desmosterol (0.25, 0.5 and 1.0 µm) and 4 h LPS stimulation. (A) Tnf-α concentrations, (B) <i>LXRα</i> mRNA, (C) <i>Abca1</i> mRNA, and (D) <i>Abcg1</i> mRNA expression after sitostanol exposure, (E) Tnf-α mRNA, (F) <i>LXRα</i> mRNA, (G) <i>Abca1</i> mRNA, and (H) <i>Abcg1</i> mRNA expression after desmosterol exposure. Data were set relative to cells incubated with cyclodextrin (carrier control). *P<0.05; **P<0.01; ***P<0.001.</p>