Figure_7.tif (560.45 kB)
Effect of plant stanols on macrophages in vitro.
figure
posted on 2014-10-30, 03:58 authored by Jogchum Plat, Tim Hendrikx, Veerle Bieghs, Mike L. J. Jeurissen, Sofie M. A. Walenbergh, Patrick J. van Gorp, Els De Smet, Maurice Konings, Anita C. E. Vreugdenhil, Yasmin Dias Guichot, Sander S. Rensen, Wim A. Buurman, Jan Willem M. Greve, Dieter Lütjohann, Ronald P. Mensink, Ronit Shiri-SverdlovChanges in Tnf-α concentrations in supernatant and LXR target gene expression of bone marrow derived macrophages after incubation with sitostanol (0.6 and 1.2 µm) or desmosterol (0.25, 0.5 and 1.0 µm) and 4 h LPS stimulation. (A) Tnf-α concentrations, (B) LXRα mRNA, (C) Abca1 mRNA, and (D) Abcg1 mRNA expression after sitostanol exposure, (E) Tnf-α mRNA, (F) LXRα mRNA, (G) Abca1 mRNA, and (H) Abcg1 mRNA expression after desmosterol exposure. Data were set relative to cells incubated with cyclodextrin (carrier control). *P<0.05; **P<0.01; ***P<0.001.
