Figure_5.tif (1.61 MB)
Effect of LPAATβ on tumor growth in the orthotopic model of osteosarcoma.
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posted on 2013-02-20, 22:06 authored by Farbod Rastegar, Jian-Li Gao, Deana Shenaq, Qing Luo, Qiong Shi, Stephanie H. Kim, Wei Jiang, Eric R. Wagner, Enyi Huang, Yanhong Gao, Jikun Shen, Ke Yang, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Jinyong Luo, Xiaoji Luo, Yang Bi, Xing Liu, Mi Li, Ning Hu, Linyuan Wang, Gaurav Luther, Hue H. Luu, Rex C. Haydon, Tong-Chuan HeA. Xenogen IVIS 200 bioluminescence imaging of orthotopic tumor growth. Athymic nude mice were periosteally injected at proximal tibia with 143B cells infected with AdR-LPAATβ, AdRFP, or AdR-siLPAATβ for 15 h (106 cells/injection). Animals were subjected to Xenogen imaging at the indicated time points. Representative imaging results at 37 days post injection are shown. B. Quantitative analysis of Xenogen imaging signal intensity (photons/sec/cm2/steradian) over the time after injection. C. Tumor growth as determined by tumor volume. The dimensions of injection sites were measured roughly every 3 days during the course of study. Tumor volumes (mm3) were calculated as described in Methods. “*” p-value <0.05, “**” p-value <0.001.
