Effect of AMD3100 treatment on CXC chemokine receptor 4+ (CXCR4+) cells.
Quantification of the number of total CXCR4+ cells (A), CXCR4+ von Willebrand Factor+ (vWF+) cells (B) and CXCR4+ α-smooth muscle actin+ (α-SMA+) cells (C) per vessel in pulmonary arteries of SuHx animals treated with vehicle or AMD3100. The data indicate that while the number of total CXCR4+ cells and CXCR4+ α-SMA+ cells per vessel was significantly reduced by AMD3100 treatment, there was only a small trend towards decreased number of CXCR4+ vWF+ cells per vessel in AMD3100 treated SuHx animals. n = 4 animals/group. * P<0.05, *** P<0.0001.