EP2 and EP4 receptor expression is heightened in epidermis and papillomas from Tpl2−/− mice.

Shaved wildtype and Tpl2−/− mice were treated with TPA (10 µg) for 0, 4, 8, 12, or 24 hours and analyzed for expression of EP2 (Figure 4A) or EP4 (Figure 4C). Additionally, papillomas from wildtype and Tpl2−/− mice were analyzed for expression of EP2 (Figure 4B). Magnification = 10X.