ELISA analyses of CHI3L1 protein in BALF and serum of regional inflammation-induced lung tumor mice.

Left: CHI3L1 protein concentrations in BALF and serum of doxycycline-treated and untreated bitransgenic mice. Right: ROC (Receiver Operating Characteristic) curve analyses to determine the area under the curve (AUC). Dox-: doxycycline-untreated mice; Dox+: doxycycline-treated mice without showing lung tumor; Cancer, doxycycline-treated mice with lung tumor. A) CCSP-rtTA/(TetO)7-CMV-MMP12 mice. Mean ± SD in BALF (n>7), DOX -: 49.6±22.8, DOX +: 49.4±18.1, Cancer: 159.7±22.4. Mean ± SD in serum (n>7), DOX -: 18.6±10.9, DOX +: 18.2±4.6, Cancer: 61.4±33.5. The gray lines represent the mean values; B) CCSP-rtTA/(TetO)7-CMV-Api6 mice. Mean ± SD in BALF (n>3), DOX -: 82.4±37.1, DOX +: 93.8±23.0, Cancer: 409.8±49.2. Mean ± SD in serum (n>3), DOX -: 14.0±7.2, DOX +: 30.7±43.1, Cancer: 295.2±194.0. The gray lines represent the mean values.