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E9.5 FVB/N KLF2−/− atrioventricular cushions have accumulated cells lining the AV canal.

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posted on 2013-02-14, 02:25 authored by Aditi R. Chiplunkar, Tina K. Lung, Yousef Alhashem, Benjamin A. Koppenhaver, Fadi N. Salloum, Rakesh C. Kukreja, Jack L. Haar, Joyce A. Lloyd

(A) and (C) are WT (n = 4) and (B) and (D) are KLF2−/− (n = 4) hearts. Micrographs A and B (magnification 50X) show atrial (At) and ventricular (V) chambers. The boxes or brackets enclose the endocardial cushions (EC) shown at higher magnification in C and D (400X). Endo: Endocardial cells; Myo: Myocardium; Ery: erythroid cells; Mes: Mesenchymal cells. (E) Bar chart representing the number of cells/mm2 lining the AV canal of E9.5 WT and KLF2−/− embryos. The Student’s t-test indicates that the number of cells is significantly greater in KLF2−/− than in WT (p = 0.0078). n = 4.

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