E2f4 deficiency limits expansion of the B lineage in response to Myc.

(A) The percentage of B lineage cells (B220+) within the bone marrow of normal and pretumorous E2F4 cohort mice with the indicated genotypes. (B) Proportions of bone marrow B lineage cell populations (B220+), from early to more mature stages, across the E2F4 cohort: surface immunoglobulin negative cells, IgM positive IgD negative B cells, IgM positive IgD positive B cells, and IgM negative IgD positive B cells. (C) The proportion of immature B lineage cells (B220+ CD43+) in the bone marrow of non-transgenic and pretumorous E2F4 mice of the indicated genotypes.



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