Figure_6.tif (358.66 kB)
E2f4 deficiency limits expansion of the B lineage in response to Myc.
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posted on 2009-09-11, 01:23 authored by Rachel E. Rempel, Seiichi Mori, Maura Gasparetto, Michele A. Glozak, Eran R. Andrechek, Steven B. Adler, Nina M. Laakso, Anand S. Lagoo, Robert Storms, Clay Smith, Joseph R. Nevins(A) The percentage of B lineage cells (B220+) within the bone marrow of normal and pretumorous E2F4 cohort mice with the indicated genotypes. (B) Proportions of bone marrow B lineage cell populations (B220+), from early to more mature stages, across the E2F4 cohort: surface immunoglobulin negative cells, IgM positive IgD negative B cells, IgM positive IgD positive B cells, and IgM negative IgD positive B cells. (C) The proportion of immature B lineage cells (B220+ CD43+) in the bone marrow of non-transgenic and pretumorous E2F4 mice of the indicated genotypes.
