Dual role of CDK1 in tumorigenesis and chemotherapeutic sensitivity.
A. A model of CDK1 activation. When inactive p-Y15/T14 CDK1 is dephosphorylated on Y15 and T14 by CDC25A, it associates with Cyclin A/B and becomes active within the cytoplasm, then quickly translocates into the nucleus, where it promotes G1 to S and G2/M transitions. Active CDK1 is inactivated via sequential phosphorylation of Y15 and T14 by Wee1 and Myt1, and sequestrated by 14-3-3σ in the cytoplasm. This process repeats with cell cycling to drive cellular proliferation. B. A diagram to illustrate the dual role of CDK1 as a tumorigenic driver in lung carcinogenesis and a sensitizer in chemotherapeutic responsiveness.