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Copy Number Variation (CNV) indicates that BRAF is amplified and bisected in resistant clones.

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posted on 2012-06-22, 00:03 authored by Nathan V. Lee, Maruja E. Lira, Adam Pavlicek, Jingjing Ye, Dana Buckman, Shubha Bagrodia, Sreesha P. Srinivasa, Yongjun Zhao, Samuel Aparicio, Paul A. Rejto, James G. Christensen, Keith A. Ching

Relative to GTL16, CNV analysis identifies a region of increased copy number at 7q34, with a breakpoint within the BRAF locus in GTL16R1 and GTL16R3. In conjunction with Affymetrix expression analysis, genes within the amplified regions are coordinately over-expressed (indicated in red) normalized to GTL16. Expression of the BRAF transcript is increased over GTL16.

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