Fig_7.tif (3.2 MB)
Confocal microscopic images of Streptococcus pneumoniae D39 biofilms grown with and without pyrimidinedione.
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posted on 2015-10-02, 03:23 authored by Mukesh Kumar Yadav, Yoon Young Go, Sung-Won Chae, Jae-Jun Song(A & B) Representative confocal images of a control sample. The biofilms in the control sample were thick with an organized 3-dimesional structure. (C & D) Representative confocal images of biofilms grown with 7 μM/ml pyrimidinedione. The pyrimidinedione-grown biofilms were thin and disorganized, with clumps of cells attached to the bottom of plate.
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Small Molecule DAM InhibitorcckStreptococcus pneumoniae D 39pneumococcal biofilm growthnovel antimicrobial compoundsgene expressionplanktonic cell growthhost defense systemsmicroarray analysisgene expression profilesscanning electron microscopy analysisamcmolecule Dam inhibitorstudy gene expressionmiddle ear epithelium cell linemssaextracellular polysaccharide matrixbiofilm formationexhibit eukaryotic cell toxicityStaphylococcus epidermidis biofilm growthscanning electron microscopyconfocal microscopy analysismicrotiter plate assayVitro Streptococcus pneumoniaeDNA adenine methyltransferasemrsapyrimidinedioneStreptococcus pneumoniae biofilm formationDisrupts Streptococcus pneumoniae Biofilm Growth
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