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Confirmed novel PKD1 inhibitors display competitive activity with respect to ATP.
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posted on 2011-10-05, 02:09 authored by Elizabeth R. Sharlow, Gabriela Mustata Wilson, David Close, Stephanie Leimgruber, Manuj Tandon, Robyn B. Reed, Tong Ying Shun, Q. Jane Wang, Peter Wipf, John S. LazoSelect PKD1 inhibitors were evaluated to determine if they were mixed, competitive or non-competitive inhibitors of ATP. Panels A and B, representative Michaelis-Menten and Lineweaver-Burk plots of CID 5086667. This compound was found to be an ATP-competitive inhibitor. Data presented were representative of three independent experiments.
