Collagen X perinatal lethal mice have increased levels of serum antibodies.

Sera from week-3 wild type (WT), collagen X transgenic (Tg), null (KO) and perinatal lethal (Tg severe and KO severe; pooled) mice were assayed for IgM and IgG antibodies with ELISA. (A-B) Total IgM and IgG serum antibody measured. (C-D) Normalized levels of IgM and IgG antibodies calculated as (ng/ml of serum antibody)/(total number of live B220 splenocytes). Numbers above the standard error of the mean are number of mice per group.