Cigarette smoke condensate (CSC) activates the HPV-16 p97 promoter in a dose-dependent manner in non-tumor lung cells after HPV-16 E6/E7 expression.

(A) BEAS-2B, (B) NL-20 cells stably transfected with HPV-16 E6/E7 oncogenes (dark) or an empty vector (gray) were transfected with the pmiR-GLO containing the full HPV-16 LCR/p97 region. The graphs are representative of three independent experiments. (* = p<0.05; ** = p<0.01; *** = p<0.001, Luc2/Reni percentage ± SEM).