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Cigarette smoke condensate (CSC) activates the HPV-16 p97 promoter in a dose-dependent manner in non-tumor lung cells after HPV-16 E6/E7 expression.

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posted on 2015-04-01, 03:13 authored by Nelson Peña, Diego Carrillo, Juan P. Muñoz, Jonás Chnaiderman, Ulises Urzúa, Oscar León, Maria L. Tornesello, Alejandro H. Corvalán, Ricardo Soto-Rifo, Francisco Aguayo

(A) BEAS-2B, (B) NL-20 cells stably transfected with HPV-16 E6/E7 oncogenes (dark) or an empty vector (gray) were transfected with the pmiR-GLO containing the full HPV-16 LCR/p97 region. The graphs are representative of three independent experiments. (* = p<0.05; ** = p<0.01; *** = p<0.001, Luc2/Reni percentage ± SEM).

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