Cardiac remodeling reverses following treatment with Ad-IL-17AR:Fc in chronic viral myocarditis in mice.
Groups of BALB/c mice were infused with Ad:null, Ad-IL-17AR:Fc or PBS. (A) Survival curves for mice after CVB3 infection. The mice in each group (n = 20) were monitored for up to 90 days after the intraperitoneal administration of CVB3. (B) Heart weight to body weight ratio (HW/BW) measured in five mice from the different groups (g/g). (C) Representative images of the heart from three mice (×50) and transthoracic M-mode tracings indicating the measurements. (D) The echocardiographic measurements are shown as the mean ± S.E.M. from five mice. LVIDS, Left ventricle internal dimension at end-systole; LVIDD, Left ventricle internal dimension at end-diastole; EF, Left ventricle ejection fraction; LVFS, Left ventricle fraction shortening. The values are expressed as the mean ± S.E.M. of five mice from each group. **p<0.01, *p<0.05 vs control.