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CXCR4 and SDF-1 mRNA in sham-operated and subtotally nephrectomized (SNx) rats.
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posted on 2014-03-17, 02:43 authored by Li-Hao Chen, Suzanne L. Advani, Kerri Thai, M. Golam Kabir, Manish M. Sood, Ian W. Gibson, Darren A. Yuen, Kim A. Connelly, Philip A. Marsden, Darren J. Kelly, Richard E. Gilbert, Andrew AdvaniCXCR4 expression is increased in the kidneys of SNx rats (A), whereas SDF-1 is reduced (B). The kidneys of SNx rats also demonstrated an upregulation of the pro-fibrotic growth factor, transforming growth factor-β (TGF-β) (C). In cultured NRK-49F renal fibroblasts, recombinant TGF-β downregulated SDF-1 mRNA, with this effect being attenuated by HDAC inhibition with vorinostat (D). *p<0.001 vs. sham, †p<0.05 vs. sham, ‡p<0.01 vs. sham, §p<0.001 vs. control, ¶p<0.001 vs. TGF-β.
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anatomyCardiovascular anatomycell biologyCellular structures and organellesExtracellular matrixMolecular cell biologyorganismsanimalsvertebratesmammalsrodentsratscardiologyNephrologyChronic kidney diseaseTubulointerstitial diseaseVascular medicineblood pressurehypertensionModel organismsAnimal modelssdf-1mrnasham-operatedsubtotallynephrectomized
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