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CCL3 is not involved in the recruitment of NK cells during RSV infection.
figure
posted on 2013-02-21, 02:32 authored by John S. Tregoning, Philippa K. Pribul, Alasdair M. J. Pennycook, Tracy Hussell, Belinda Wang, Nicholas Lukacs, Jurgen Schwarze, Fiona J. Culley, Peter J. M. OpenshawChemotaxis of enriched NK cells to recombinant CCL3 or supernatant (supe) from RSV, UV-RSV, or control exposed macrophages; anti-CCL3, anti-TNF or control antibody was used to assess the chemotactic effect of specific mediators (A). BALB/c mice were treated on day −1 and +1 of RSV infection with anti-CCL3 (white bars) or control Ig (black bars). Lung cell number (B), percentage lung NK cells (C) and lung viral load (D) on day 4 post infection. Bars represent n≥3 ± SEM, ** p<0.01.