Body weight and water consumption are not affected by LM11A-31 treatment in Tg2576 mice.

(A) Body weight of 17 month old female Tg2576 mice treated with LM11A-31 for 3 months (nTg-Veh, n = 7 mice; Tg2576-Veh, n = 6; Tg2576-31, n = 5; nTg–LM11A-31, n = 4). Starting at treatment week 6, Tg2576 mice weighed less than WT mice; LM11A-31 had no effect on this measure. Statistical significance was determined using repeated measures ANOVA with Dunnett's post-hoc test. (B) Average grams of water consumed by Tg2576 mice over 3 days was significantly greater than nTg mice; LM11A-31 had no effect on this measure. Statistical significance was determined using two-tailed Student's t-test. *p≤0.05 vs. nTg Veh.