Biophysical properties of WT and mutants TRPM4 channel in whole-cell configuration.

(A): Representative current tracings recorded in the whole cell conditions (ramp protocol under the traces) (B): Mean current density for WT and mutants estimated using the maximal current recorded during the ending step of 20 ms at Vm = +100 mV (see A) and reported to cell capacitance. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, n.s.: not significant. Numbers in bars = number of experiments. Error bar: standard error of the mean.