Bacterial replication in lungs and spleen of BALB/c mice vaccinated with MGM1991, or BCG and challenged with 105 CFU of virulent luminescent M. tuberculosis.

Mean number of bacteria in lungs and spleen of C57BL/6 mice vaccinated with 5x105CFU of MGM1991 mutant or BCG or unvaccinated mice (naïve), challenged 12 weeks later with 105CFU of virulent M.tb by the intratracheal route and sacrificed 6 or 12 weeks after challenge. Results are reported as mean log10 relative light units (RLU) ± SD of 5 mice tested individually; * P < 0.05; ** P < 0.01 (Mann-Whitney test).