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Bacterial replication in lungs and spleen of BALB/c mice vaccinated with HMA or BCG and challenged with 105 CFU of virulent luminescent M. tuberculosis.

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posted on 2013-10-17, 04:37 authored by Dorsaf Hedhli, Olivier Denis, Daniel Barkan, Mamadou Daffé, Michael S. Glickman, Kris Huygen

Mean number of bacteria in lungs and spleen of BALB/c mice vaccinated with 5x105CFU of HMA mutant or BCG or unvaccinated mice (naïve), challenged 12 weeks later with 105CFU of virulent M.tb by the intratracheal route and sacrificed 6 or 12 weeks after challenge. Results are reported as mean log10 relative light units (RLU) ± SD of 5 mice tested individually; ** P<0,01; *** P<0.001 (Mann-Whitney test).

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