Association between EBV infection and breast carcinoma risk (ORs).

Ten studies that adopted non-breast-cancer control groups [2]–[11] were selected for the analysis of EBV infection and human breast carcinoma risk. One [7] was excluded automatically after data pooling for the absence of EBV DNA in both patient and control groups. Random-effects model was chosen to estimate the ORs after pooling due to the high heterogeneity among these studies (I² = 75.9%, P = 0.000). A significant, 6.29-fold (95% CI = 2.13–18.59) increased breast carcinoma risk in patients with an EBV infection was shown.