Analysis workflow of 59 cervical cancer cases.
Figure shows the analysis workflow of the 59 CC cases explored in this study. All CC samples were HPV16 positive and were investigated with microarrays–31 for mapping CN-AG and 55 for global gene expression, with 27 CCs in common. These 27 CCs were used for the analyses of global gene expression and the correlation between the CN-AG and gene expression. For the hierarchical clustering analysis, the expression profiles of the 55 CC samples were included. Five-year survival was investigated in 55 patients, 51 explored for gene expression and 28 for CN alterations, with 24 CCs in common. See material and methods section for details of the procedures.