Age-dependent decline of cobblestone area formation in <i>Npm1<sup>wt/c+</sup></i> mice.

<p>(<b>A</b>) The cobblestone area formation (arrows) is obviously inhibited in <i>Npm1<sup>wt/c+</sup></i> HSPC. (<b>B</b>) The cobblestone area numbers are also much lower in mutant mice. The difference seems more augmented as mice became older (n = 7 each). (C) The mutant mice with MPD exhibited even more severe compromised cobblestone area formation when compared with mutant but non-MPD mice (<i>P</i><0.001, one bar represents triplicate experiments from one mouse).</p>




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