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Accelerated paralysis phenotypes for TDP-43 and FUS transgenics in liquid culture.

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posted on 2012-02-21, 02:27 authored by Alexandra Vaccaro, Arnaud Tauffenberger, Dina Aggad, Guy Rouleau, Pierre Drapeau, J. Alex Parker

(A) Paralysis phenotypes resolve over a number of hours for wtTDP-43 and mTDP-43 worms grown in liquid culture. mTDP-43 worms have a faster rate of paralysis compared to wtTDP-43 transgenics (P<0.001). (B) Transgenic mFUS worms show motility defects and become paralysed at a rate faster than wtFUS controls (P<0.001). (C) unc-47p::GFP transgenics have an increased rate of paralysis compared to non-transgenic N2 worms (P<0.001).

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