Fig_5.tif (2.7 MB)
A) Visant plot of top 1500 gene connections in 22q11DS Purple module, which is significantly associated with a psychotic disorder (p = .03) and positive symptoms (p = 5.0e-8).
figure
posted on 2015-07-22, 03:02 authored by Maria Jalbrzikowski, Maria T. Lazaro, Fuying Gao, Alden Huang, Carolyn Chow, Daniel H. Geschwind, Giovanni Coppola, Carrie E. BeardenGenes that are the most strongly connected are listed in a larger font than less connected genes. Genes found in the Purple module that overlap with genes in the Salmon module, which was validated in a set of antipsychotic naive schizophrenia patients module [51] are highlighted in red. B) Visant plot of top 1500 gene connections in 22q11DS Royal Blue module, which is significantly associated with an ASD diagnosis. Genes that are most strongly connected are listed in larger font than other, less connected genes. Genes found in the Royal Blue module that overlap with genes in M12 autism-related brain expressed module [52] are highlighted in red.
History
Usage metrics
Categories
Keywords
idiopathic psychosisexpression changesantipsychotic medication userisk factors22 q 11.2 Deletion Syndromeresponse pathwaysWGCNA analyseshttranscriptional regulationidiopathic ASD.ConclusionThese findingsFunctional Pathways Relatedbrain tissue22 q 11DS patientsgeneidiopathic schizophrenia22 q 11DSperipheral blooddeletion characteristics22 q 11DS individualspathways dysregulated22 q 11DS carriersmoduleTranscriptome Profiling3 Mb deletiondata mining techniquesdeletion breakpointsdeGenomic Analysesphenotypic variationaCGH arrayspectrum disorderstranscriptional changes
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC