pgen.1006853.g005.tif (2.02 MB)

Various oncogenes in triple-negative breast cancer (TNBC).

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posted on 21.06.2017 by Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda, Natsuko Hama, Mihoko Saito-Adachi, Kazuhito Sato, Shinji Kohsaka, Eirin Sai, Masako Ikemura, Shigeru Yamamoto, Tomoko Ogawa, Masashi Fukayama, Keiichiro Tada, Yasuyuki Seto, Shinichi Morishita, Shoichi Hazama, Tatsuhiro Shibata, Yoshihiro Yamashita, Hiroyuki Mano

(A) NFKB1 mutations found in this study (above, TNBC) and in the TCGA data (below, various cancers). (B) Mutations in NOTCH1 found in this study (above, TNBC) and in the TCGA data (below, TNBC). (C) Mutations in ERBB2 found in this study (above, TNBC) and in the TCGA data (below, BC). (D) Diagram of the protein encoded by the FGFR3-CAT fusion gene. IG, immunoglobulin-like domain; TyrKc, tyrosine-protein kinase catalytic domain. (E) Anchorage-independent growth of 3T3 cells expressing the indicated proteins. The diagrams of the proteins in (A), (B), and (C) were generated using protein painter (http://explore.pediatriccancergenomeproject.org/proteinPainter). Mutations expected to be activating according to previous reports or experiments in this study are highlighted in red.

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