Fig 1.TIF (704.76 kB)
Validation of Y4R PAM activity and subtype selectivity of initial Ca2+-flux-based screen hit compounds in an inositol phosphate accumulation assay.
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posted on 2016-06-13, 08:08 authored by Gregory Sliwoski, Mario Schubert, Jan Stichel, David Weaver, Annette G. Beck-Sickinger, Jens Meiler(A) Compound structures. (B) Effect of 10 μM compound on submaximal YR activation by 1 nM ligand, which represents EC20-EC60 (Y1,2,5R: NPY; Y4R: PP). Data represent the mean ± SEM of two independent experiments each performed in quadruplicate (*** p ≤ .001 Bonferroni).
