pbio.3000688.g002.tif (943.84 kB)

UA increases EE and adaptive thermogenesis.

figure

posted on 2020-03-27, 17:34 authored by Bo Xia, Xiao Chen Shi, Bao Cai Xie, Meng Qing Zhu, Yan Chen, Xin Yi Chu, Guo He Cai, Min Liu, Shi Zhen Yang, Grant A. Mitchell, Wei Jun Pang, Jiang Wei Wu

(A) Oxygen consumption measured by calorimetry in UA-treated and control mice (n = 6). (B) EE. (C) EE values adjusted for lean mass using ANCOVA. (D) Regression of EE against lean mass. (E) Locomotor activity measured by calorimetry in UA-treated and control mice (n = 6). (F) RER. (G) The body temperature of mice placed at room temperature (21°C) (n = 6). (H) Representative infrared images of mice. Images are displayed using the rainbow high-contrast color palette in FLIR Research. (I) Body temperature of mice placed at 4°C at the indicated time points (n = 6). (J) Oxygen consumption. (K) NE-stimulated whole-body oxygen consumption in mice at 4°C (n = 6). The underlying data for this figure can be found in S1 Data. EE, energy expenditure; NE, norepinephrine; RER, respiratory exchange ratio; UA, urolithin A.