Tissue hemoglobin concentrations, volume-weighted tissue blood oxygen saturations Y and length-weighted blood oxygenation S (Case CMPR).

This figure is the analog of Fig 9, but for case CMPR. Each of the 90 simulation runs was carried out with a different randomly selected factor ξcpr for reducing all tumor vessel radii (s. Eq (40)) simulating solid stress. Fig 10 Panel A-C correlate tissue hemoglobin concentration cHb, RBC-volume-weighted blood oxygen saturation Y and length-weighted blood oxygen saturation S of tumor (t = 600 h) and normal (t = 0 h) tissue, respectively. In Fig 10D tissue blood oxygenation Y is plotted versus tissue hemoglobin concentration cHb separately for tumors (colored) and normal tissue (black). Fig 10E and 10F correlate tissue blood oxygen saturation Y of tumors with factor ξcpr and average vessel radius r. Generally, Ytum decreases with decreasing average r and decreasing ξcpr, corresponding to higher compression. Black lines in (A), (B) and (C) represent diagonals separating tumor data above from below normal. The color code to identify root node geometry is the same as in Fig 9.