Time-dependent changes in the stress-induced anxiety-like behaviors in rats as determined by EPM and ETM.

(A) Percent open arm entry, (B) percent open arm time, (C) percent closed arm entry, (D) percent closed arm time, and (E) total number of entries in 1-, 4-, and 8-week stressed male rats, as determined by elevated plus-maze (EPM). (F) One-way escape latency, (G) baseline time, (H) avoidance 1, and (I) avoidance 2 in stressed rats, as determined by elevated T-maze (ETM). Numbers of animals are noted in parentheses. *p < 0.05, **p < 0.01, ***p < 0.001 stress vs. control.