Thrombin cleaves S3ED and S4ED from ex vivo human lung slices.

Human lung slices were treated with vehicle or thrombin (24hr; 10 U/ml) and then imaged on a confocal microscope to assess the effect on SDC ectodomain expression. The data shown in Fig 4 suggest that both S3ED (n = 1) and S4ED (n = 1) have decreased expression in human lung slices following thrombin treatment.