The threshold for nociceptive response measured by calibrated forceps was stable for 5 days.

<p>(A) Time courses of the nociceptive response threshold of 6 mice over 5 days. A repeated-measured one-way ANOVA revealed that there was no significant difference among days (F<sub>4,20</sub> = 0.3240, <i>p</i> = 0.8585). (B) The thresholds were replotted as the mean ± SEM for 6 animals for each day.</p>