The strength of <i>Plk1</i> inhibition sets the relative prominence of cell cycle failure modes.

<p>Stacked bar charts showing the relative occurrence of normal cell cycle completion (<i>mustard</i>), G2 → G1 reset followed by genome duplication (<i>purple</i>), aberrant mitosis followed by genome duplication (<i>turquoise</i>), failed cytokinesis followed by genome duplication (<i>blue</i>) and apoptosis (<i>dark red</i>) relative to the rate of cell cycle in wild-type cells (<i>black dashed line</i>) at growth factor exposure of 40%, 60% and 80% in <i>Plk1</i>-deficient cells using synchronous (<i>top</i>) and biased asynchronous update (<i>bottom</i>).</p>