The probability density curves for the highly relevant protein pocket properties of three classes of proteins.

The distribution of (a) median contact area, (b) volume of three classes of protein pockets in the reverse docking by DOCK. The distribution of (c) median contact area, (d) phobic of three classes of protein pockets in the reverse docking by Glide. The distribution of (e) median contact area, (f) size of three classes of protein pockets in the reverse docking by AutoDock Vina.