The performance of network-based algorithms in predicting the CDR of patients using models trained on preclinical CCL samples.

The third column shows the number of drugs for which a statistically significant discrimination between resistant and sensitive patients was obtained (one-sided Mann Whitney U test). The fourth column shows the total number of drugs included in the evaluation, and the fifth column shows the combined p-value (using Fisher’s method) for all the drugs in the analysis. As a point of comparison, LASSO without the use of any network yielded p-value < 0.05 for five of 12 drugs, with combined p-value of 5.21E-09 (Table 1).