The particle-based model produces different calcium activity regimes depending on parameter values.

Color-coded map of variation of the peak frequency, expressed as the number of calcium peaks per MC time step (A) and as the maximal number of IP₃R channel open per peak (B). The color scale is given for each map. The black area corresponds to the stationary regime. Note that the x and y-axis scales in (A) and (B) are not regularly spaced. The symbols ★, ◼ and ● locate parameter pairs that are illustrative of the three dynamical regimes shown in (C): stationary (★, μ = 5, a₁ = 0.5), blips (◼, μ = 25, a₁ = 2) and puffs (●, μ = 75, a₁ = 7). Red crosses show the locations of peaks from automatic detection. D_Ca = D_IP3 = ∞, η = 1, R_γ = 200.