The cycling regulatory cascades of cell division are robust under biased asynchronous update.

(A) Dynamics of regulatory molecule expression / activity during cell cycle entry from G0 using biased asynchronous update. X-axis: time-steps; y-axis: nodes organized in modules; orange/blue: ON/OFF. (B) Occurrence rate of normal cell cycle completion (mustard), G2 → G1 reset followed by genome duplication (purple), aberrant mitosis followed by genome duplication (turquoise), failed cytokinesis followed by genome duplication (blue) and apoptosis (dark red) per 100 timesteps, shown as stacked bar charts for increasing growth factor / Trail exposure (left/right) with random order asynchronous / biased asynchronous / synchronous update (top/middle/bottom).