The burden of trisomy 21 disrupts the proteostasis network in Down syndrome - Fig 2

<p><b>LCLs from DS patients enhanced basal levels of ROS production (A) and expression of ER stress genes (B).</b> Unstimulated DS and CTL LCLs were evaluated for basal superoxide and hydrogen peroxide production using flow cytometry. These unstimulated cells were also assessed for ER stress gene expression using qRT-PCR. N = 3; * P<0.05; ** P<0.01; *** P<0.001; **** P<0.0001.</p>