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Absence of DNAM-1 ligands does not prolong skin allograft survival.

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posted on 2016-02-03, 22:27 authored by Anna K. Kraus, Jin Chen, Ilka Edenhofer, Inga Ravens, Ariana Gaspert, Pietro E. Cippà, Steffen Mueller, Rudolf P. Wuthrich, Stephan Segerer, Guenter Bernhardt, Thomas Fehr

(A) Skin grafts from fully MHC-mismatched WT BALB/c (n = 19) or CD155 KO (n = 24) donors were performed on B6 recipients. Median survival time: 9 vs. 10 days (WT vs. CD155 KO). (B) Skin grafts from WT BALB/c (n = 7) or CD155 KO (n = 8) donors were performed on minor antigen mismatched DBA/2 recipients. Median survival time: 13 vs. 15 days (WT vs. CD155 KO). (C) Skin grafts from fully MHC-mismatched WT B6 (n = 8) or CD112 KO (n = 8) donors were performed on CBA recipients. Median survival time: 11 vs. 12 days (WT vs. CD112 KO). (D) Skin grafts from MHC I antigen mismatched B6 (n = 7) or CD112 (n = 8) donors were performed on bm1 recipients. Median survival time: 25.5 vs. 21 days (WT vs. CD112 KO, P = 0.01).

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