Telomerase activity is essential for frequent GCRs in taz1Δ and rap1Δ strains.

(A) GCR rates of wild-type, taz1Δ, rap1Δ, and rad2Δ strains in the presence or absence of pof8+. (B) GCR rates of trt1Δ strains in the presence or absence of a pREP1-trt1+ plasmid (Trt1 plasmid). The GCR assay was performed in YES media, in which the nmt1 promoter in the plasmid has a moderate activity [69]. Asterisks and NS represent significant differences (P < 0.05 and P>0.05) from the wild type strain, respectively. P-values were obtained by the two-tailed Mann–Whitney test.