pone.0210883.g001.tif (345.93 kB)
Synergistic effects of azole antifungals and the V-ATPase inhibitor bafilomycin B1 against C. glabrata wild-type strain.
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posted on 2019-01-23, 18:38 authored by Asuka Minematsu, Taiga Miyazaki, Shintaro Shimamura, Hiroshi Nishikawa, Hironobu Nakayama, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Yoshifumi Imamura, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae, Koichi IzumikawaCheckerboard assay was performed using serial 2-fold dilutions of drugs. (A) Data for the combination of fluconazole and bafilomycin B1. (B) Data for the combination of voriconazole and bafilomycin B1. Plates were incubated at 35°C for 48 h and the optical density at 600 nm (OD600) was determined. The graphs are representative of three independent replicate experiments.
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Candida albicansantifungal agentsVPH 2pH homeostasisfindings supportV-ATPase functionvacuolar membranesreconstituted strainsplecomacrolide V-ATPase inhibitor bafilomycin B 1iron limitationCandida glabrata Vacuolar proton-translocating ATPaseVacuolar proton-translocating ATPaseantifungal resistancevirulencemultidrug resistancepathogen Candida glabrataassembly factorglabrata Δ vph 2mouse modelintracellular ion homeostasisazole antifungal agentsVPH 2 gene encodingglabrata wild-type straincalcineurin inhibitor FK 506stressantifungal strategiesacidic pH
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