pone.0214737.g002.tif (5.78 MB)
Syndecan family is expressed in microvasculature of human lung.
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posted on 2019-05-15, 17:25 authored by Melanie Jannaway, Xiaoyuan Yang, Jamie E. Meegan, Danielle C. Coleman, Sarah Y. YuanSections of agarose-inflated human lung were stained for each of the four syndecan ectodomains and the endothelial cell marker, PECAM-1. Confocal images demonstrate co-localization of PECAM-1 with all four syndecan ectodomain proteins, indicating expression throughout the pulmonary microvasculature. Scale bars: 100 μm.
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thrombin receptor PAR 1.barrier integritydisease statesbarrier functionsyndecan -3 ectodomain fragmentsSyndecan proteinsplasma protein leakageglycocalyxRho kinase inhibitorELISAVE-cadherin-based adherens junction disorganizationalbumin-bound Evanstransmission electron microscopysyndecan subtypesF-actin stress fibersmouse lungintercellular gapstransmigrating cellsbarrier dysfunction Objectiveparacellular hyperpermeabilitythrombotic disease statescleavage productsparacellular permeabilityblot analysislung microvasculature
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