Structures of human Drosha and Giardia Dicer.

Front view ribbon representation of the structure of (A) Drosha and (B) Dicer. The proteins are colored with similar colors for similar domains. Domains colors are as follow: N-terminal Platform domain (Drosha: cyan, Dicer: dark blue), putative PAZ-like and PAZ domains (Drosha and Dicer: orange), Connector (red), RIIIDa (Drosha: gold, Dicer: yellow), RIIIDb (Drosha: green-forest, Dicer: light green), Dicer Bridging domain (gray), Drosha dsRBD domain (purple). The catalytic residues of both RIIID domains are represented as magenta spheres.