Structure of the cytoplasmic segment of the AC5 isoform of adenylyl cyclase in complex with ATP and the activating G-protein Gsα viewed from the side closest to the cell membrane.

The C1 and C2 subunits of AC5 are colored blue and red respectively and Gsα is colored green. ATP is shown in a CPK representation with standard chemical coloring. A close-up view of the helix-helix interactions between AC5 and Gsα is provided (circle).