Structure of the cytoplasmic segment of the AC5 isoform of adenylyl cyclase and of its complexes with ATP and the activating G-protein Gsα viewed from the side closest to the cell membrane.

Proteins are shown as backbone ribbons. The C1 and C2 subunits of AC5 are colored blue and red respectively and Gsα is colored green. ATP is shown in a CPK representation with standard chemical coloring. In each case, the structures are averages taken from the molecular dynamics simulations described in this work.