pntd.0006575.g008.tif (586.79 kB)

Structural modelling of LdThrRS.

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posted on 2018-06-13, 17:53 authored by Sanya Chadha, Ramachandran Vijayan, Sakshi Gupta, Manoj Munde, Samudrala Gourinath, Rentala Madhubala

(A) Structural superposition of LdThrRS model with human ThrRS with an RMSD of 0.21Å. The LdThrRS protein is shown in brown color, and human ThrRS is displayed as green. (B) Active site residues are labelled as sticks.

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parasite threonyl tRNA synthetase target Background Aminoacyl tRNA synthetases Methodology Recombinant Ld ThrRS Ld ThrRS aminoacylation activity IC 50 Leishmania donovani threonyl tRNA synthetase Conclusions Recombinant Ld ThrRS r Ld ThrRS drug discovery efforts

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